SPDR S&P Biotech ETF (XBI), issued by State Street, reported 155 long positions and $10.7B in net assets in its Jun 2026 N-PORT filing. The ten largest positions account for 17.99% of net assets.
Reporting period: 30 Jun 2026 · 9 filings on file · N-PORT is filed monthly and published quarterly, roughly 60 days in arrears
Net assets
$10.7B
As of Jun 2026
Positions
155
Long positions in the filing
Top 10 weight
17.99%
Top 25: 35.39%
Effective holdings
80
Moderately concentrated
Cash
0.00%
Share of net assets
Securities on loan
11.6348%
99 positions on loan
Sector exposure
4 sectors · Jun 2026
Health Care88.89%
Funds5.59%
Unclassified5.08%
Financials0.44%
Ten largest holdings
Top 10 of 161 positions · Jun 2026
Ten largest holdings reported by XBI as of 30 Jun 2026
#
Security
CUSIP
Value
% of net assets
1
STATE ST INST US GOV MM-PREM
857492706
$630.6M
5.87%
2
APOGEE THERAPEUTICS INC
03770N101
$159.8M
1.49%
3
MODERNA INC
60770K107
$151.6M
1.41%
4
TWIST BIOSCIENCE CORP
90184D100
$151.1M
1.41%
5
ORUKA THERAPEUTICS INC
687604108
$148.0M
1.38%
6
KYMERA THERAPEUTICS INC
501575104
$145.9M
1.36%
7
VIKING THERAPEUTICS INC
92686J106
$140.0M
1.30%
8
PRAXIS PRECISION MEDICINES I
74006W207
$138.5M
1.29%
9
ERASCA INC
29479A108
$136.4M
1.27%
10
REVOLUTION MEDICINES INC
76155X100
$129.3M
1.20%
Full holdings, position changes between periods, fund overlap, cross-fund crowding and securities lending detail for XBI are in the ETF X-Ray dashboard.